TY  - JOUR
PY  - 2022//
TI  - Fall risk, sleep behavior, and sleep-related movement disorders in young urbanites exposed to air pollution
JO  - Journal of Alzheimer's disease
A1  - Calderón-Garcidueñas, Lilian
A1  - Kulesza, Randy
A1  - Greenough, Glen P.
A1  - García-Rojas, Edgar
A1  - Revueltas-Ficachi, Paula
A1  - Rico-Villanueva, Adriana
A1  - Flores-Vázquez, Jorge Orlando
A1  - Brito-Aguilar, Rafael
A1  - Ramírez-Sánchez, Silvia
A1  - Vacaseydel-Aceves, Nora
A1  - Cortes-Flores, Ana Paulina
A1  - Mansour, Yusra
A1  - Torres-Jardón, Ricardo
A1  - Villarreal-Ríos, Rodolfo
A1  - Koseoglu, Emel
A1  - Stommel, Elijah W.
A1  - Mukherjee, Partha S.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Quadruple aberrant hyperphosphorylated tau, amyloid-β, α-synuclein, and TDP-43 pathology had been documented in 202/203 forensic autopsies in Metropolitan Mexico City ≤40-year-olds with high exposures to ultrafine particulate matter and engineered nanoparticles. Cognition deficits, gait, equilibrium abnormalities, and MRI frontal, temporal, caudate, and cerebellar atrophy are documented in young adults. <br><br>OBJECTIVE: This study aimed to identify an association between falls, probable Rapid Eye Movement Sleep Behavior Disorder (pRBD), restless leg syndrome (RLS), and insomnia in 2,466 Mexican, college-educated volunteers (32.5±12.4 years). <br><br>METHODS: The anonymous, online study applied the pRBD and RLS Single-Questions and self-reported night-time sleep duration, excessive daytime sleepiness, insomnia, and falls. <br><br>RESULTS: Fall risk was strongly associated with pRBD and RLS. Subjects who fell at least once in the last year have an OR = 1.8137 [1.5352, 2.1426] of answering yes to pRBD and/or RLS questions, documented in 29% and 24% of volunteers, respectively. Subjects fell mostly outdoors (12:01 pm to 6:00 pm), 43% complained of early wake up hours, and 35% complained of sleep onset insomnia (EOI). EOI individuals have an OR of 2.5971 [2.1408, 3.1506] of answering yes to the RLS question. <br><br>CONCLUSION: There is a robust association between falls, pRBD, and RLS, strongly suggesting misfolded proteinopathies involving critical brainstem arousal and motor hubs might play a crucial role. Nanoparticles are likely a significant risk for falls, sleep disorders, insomnia, and preventable neurodegenerative lethal diseases, thus characterizing air particulate pollutants' chemical composition, emission sources, and cumulative exposure concentrations are strongly recommended.<p />  <p>Language: en</p>
LA  - en
SN  - 1387-2877
UR  - http://dx.doi.org/10.3233/JAD-220850
ID  - ref1
ER  -