TY  - JOUR
PY  - 2022//
TI  - The role of puberty and sex on brain structure in adolescents with anxiety following concussion
JO  - Biological psychiatry: cognitive neuroscience and neuroimaging
A1  - Lima Santos, João Paulo
A1  - Kontos, Anthony P.
A1  - Holland, Cynthia L.
A1  - Suss, Stephen J. Jr
A1  - Stiffler, Richelle S.
A1  - Bitzer, Hannah B.
A1  - Colorito, Adam T.
A1  - Shaffer, Madelyn
A1  - Skeba, Alexander
A1  - Iyengar, Satish
A1  - Manelis, Anna
A1  - Brent, David
A1  - Shirtcliff, Elizabeth A.
A1  - Ladouceur, Cecile D.
A1  - Phillips, Mary L.
A1  - Collins, Michael W.
A1  - Versace, Amelia
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Adolescence represents a window of vulnerability for developing psychological symptoms following concussion, especially in girls. Concussion-related lesions in emotion regulation circuits may help explain these symptoms. However, the contribution of sex and pubertal maturation remains unclear. Using the neurite density index (NDI) in emotion regulation tracts (left/right cingulum bundle [CB], forceps minor [FMIN], and left/right uncinate fasciculus), we sought to elucidate these relationships. <br><br>METHODS: No adolescent had a history of anxiety and/or depression. The Screen for Child Anxiety Related Emotional Disorders and Children's Depression Rating Scale were used at scan to assess anxiety and depressive symptoms in 55 concussed adolescents (41.8% girls) and 50 control adolescents with no current/history of concussion (44% girls). We evaluated if a mediation-moderation model including the NDI (mediation) and sex or pubertal status (moderation) could help explain this relationship. <br><br>RESULTS: Relative to control adolescents, concussed adolescents showed higher anxiety (p =.003) and lower NDI, with those at more advanced pubertal maturation showing greater abnormalities in 4 clusters: the left CB frontal (p =.002), right CB frontal (p =.011), FMIN left-sided (p =.003), and FMIN right-sided (p =.003). Across all concussed adolescents, lower NDI in the left CB frontal and FMIN left-sided clusters partially mediated the association between concussion and anxiety, with the CB being specific to female adolescents. These effects did not explain depressive symptoms. <br><br>CONCLUSIONS: Our findings indicate that lower NDI in the CB and FMIN may help explain anxiety following concussion and that adolescents at more advanced (vs less advanced) status of pubertal maturation may be more vulnerable to concussion-related injuries, especially in girls.<p />  <p>Language: en</p>
LA  - en
SN  - 2451-9030
UR  - http://dx.doi.org/10.1016/j.bpsc.2022.09.013
ID  - ref1
ER  -