TY  - JOUR
PY  - 2022//
TI  - Characterization of material properties and deformation in the ANGUS phantom during mild head impacts using MRI
JO  - Journal of the mechanical behavior of biomedical materials
A1  - Knutsen, Andrew K.
A1  - Vidhate, Suhas
A1  - McIlvain, Grace
A1  - Luster, Josh
A1  - Galindo, Eric J.
A1  - Johnson, Curtis L.
A1  - Pham, Dzung L.
A1  - Butman, John A.
A1  - Mejia-Alvarez, Ricardo
A1  - Tartis, Michaelann
A1  - Willis, Adam M.
SP  - e105586
EP  - e105586
VL  - 138
IS  - 
N2  - Traumatic brain injury (TBI) is a major health concern affecting both military and civilian populations. Despite notable advances in TBI research in recent years, there remains a significant gap in linking the impulsive loadings from a blast or a blunt impact to the clinical injury patterns observed in TBI. Synthetic head models or phantoms can be used to establish this link as they can be constructed with geometry, anatomy, and material properties that match the human brain, and can be used as an alternative to animal models. This study presents one such phantom called the Anthropomorphic Neurologic Gyrencephalic Unified Standard (ANGUS) phantom, which is an idealized gyrencephalic brain phantom composed of polyacrylamide gel. Here we mechanically characterized the ANGUS phantom using tagged magnetic resonance imaging (MRI) and magnetic resonance elastography (MRE), and then compared the outcomes to data obtained in healthy volunteers. The direct comparison between the phantom's response and the data from a cohort of in vivo human subjects demonstrate that the ANGUS phantom may be an appropriate model for bulk tissue response and gyral dynamics of the human brain under small amplitude linear impulses. However, the phantom's response differs from that of the in vivo human brain under rotational impacts, suggesting avenues for future improvements to the phantom.<p />  <p>Language: en</p>
LA  - en
SN  - 1751-6161
UR  - http://dx.doi.org/10.1016/j.jmbbm.2022.105586
ID  - ref1
ER  -