TY  - JOUR
PY  - 2023//
TI  - The body keeps the score: the neurobiological profile of traumatized adolescents
JO  - Neuroscience and biobehavioral reviews
A1  - Laricchiuta, Daniela
A1  - Panuccio, Anna
A1  - Picerni, Eleonora
A1  - Biondo, Daniele
A1  - Genovesi, Benedetto
A1  - Petrosini, Laura
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Trauma-related disorders are debilitating psychiatric conditions that affect people who have directly or indirectly witnessed adversities. Experiencing multiple types of traumas appears to be common during childhood, and even more so during adolescence. Dramatic brain/body transformations occurring during adolescence may provide a highly responsive substrate to external stimuli and lead to trauma-related vulnerability conditions, such as internalizing (anxiety, depression, anhedonia, withdrawal) and externalizing (aggression, delinquency, conduct disorders) problems. Analyzing relations among neuronal, endocrine, immune, and biochemical signatures of trauma and internalizing and externalizing behaviors, including the role of personality traits in shaping these conducts, this review highlights that the marked effects of traumatic experience on the brain/body involve changes at nearly every level of analysis, from brain structure, function and connectivity to endocrine and immune systems, from gene expression (including in the gut) to the development of personality.<p />  <p>Language: en</p>
LA  - en
SN  - 0149-7634
UR  - http://dx.doi.org/10.1016/j.neubiorev.2023.105033
ID  - ref1
ER  -