TY  - JOUR
PY  - 2023//
TI  - Can the optical coherence tomography findings be related with suicide attempt in bipolar disorder?
JO  - Photodiagnosis and photodynamic therapy
A1  - Onur, Özge Şahmelikoğlu
A1  - Yeşilkaya, Ümit Haluk
A1  - Subaş, Emre
A1  - Açar, Özge Pınar Akarsu
A1  - Onur, İsmail Umut
A1  - Karamustafalioğlu, Nesrin
A1  - Eris, Erdem
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: The aim was to investigate the relationship between OCT findings and suicidal behavior (SB) in patients with Bipolar Disorder type 1 (BPD1) in comparison to healthy controls. <br><br>METHODS: Forty five euthymic BPD1 patients with previous suicide attempts (BPD1+), 46 euthymic BPD1 patients without previous suicide attempts (BPD1-) and 63 healthy controls were included. The subjects were evaluated with Sociodemographic Data Form, SCID, Suicide Behaviors Questionnaire, Beck Depression Inventory, Young Mania Rating Scale and OCT. <br><br>RESULTS: All OCT measures were lower in patients with BPD1 than healthy controls (p<0.001). While no significant differences were found between (BPD1+) and (BPD1-) in all GCC levels and inferior RNFL values (p>0.05), the superior RNFL and global RNFL values were found to be lower in the (BPD1+) than in the (BPD1-) (p=0.037, p=0.028, respectively). Global RNFL was found to significantly predict suicide risk in a multivariate logistic regression model (p=0.024 Exp(B):0.930). <br><br>CONCLUSIONS: Neurodegeneration might occur during the course of BPD1 and SB. Decreased RNFL may be important for neurodegeneration related to SB.<p />  <p>Language: en</p>
LA  - en
SN  - 1572-1000
UR  - http://dx.doi.org/10.1016/j.pdpdt.2022.103268
ID  - ref1
ER  -