TY - JOUR PY - 2022// TI - Smaller rostral cingulate volume and psychosocial correlates in veterans at risk for suicide JO - Psychiatry research A1 - Goldstein, Kim E. A1 - Feinberg, Abigail A1 - Vaccaro, Daniel H. A1 - Ahmed, Tasnova A1 - Chu, King-Wai A1 - Goodman, Marianne A1 - Govindarajulu, Usha A1 - Challman, Katelyn N. A1 - Haghighi, Fatemeh A1 - Yehuda, Rachel A1 - Szeszko, Philip R. A1 - Osterberg, Terra A1 - Tang, Cheuk Y. A1 - Haznedar, M. Mehmet A1 - Hazlett, Erin A. SP - e115032 EP - e115032 VL - 320 IS - N2 - Suicide research/clinical work remain in dire need of effective tools that can better predict suicidal behavior. A growing body of literature has started to focus on the role that neuroimaging may play in helping explain the path towards suicide. Specifically, structural alterations of rostral anterior cingulate cortex (rost-ACC) may represent a biological marker and/or indicator of suicide risk in Major Depressive Disorder (MDD). Furthermore, the construct of "grit," defined as perseverance for goal-attainment and shown to be associated with suicidality, is modulated by rost-ACC. The aim was to examine relationships among rost-ACC gray matter volume, grit, and suicidality in U.S. Military Veterans. Participants were age-and-sex-matched Veterans with MDD: with suicide attempt (MDD+SA:n = 23) and without (MDD-SA:n = 37). Groups did not differ in depression symptomatology. Participants underwent diagnostic interview, clinical symptom assessment, and 3T-MRI-scan. A Group (SA-vs.-No-SA) x Cingulate-region (rostral-caudal-posterior) x Hemisphere (left-right) mixed-model-multivariate-ANOVA was conducted. Left-rost-ACC was significantly smaller in MDD+SA, Group x Cingulate-region x Hemisphere-interaction. Lower grit and less left-rost-ACC gray matter each predicted suicide attempt history, but grit level was a more robust predictor of SA. Both structural alterations of rost-ACC and grit level represent potentially valuable tools for suicide risk assessment.

Language: en

LA - en SN - 0165-1781 UR - http://dx.doi.org/10.1016/j.psychres.2022.115032 ID - ref1 ER -