TY  - JOUR
PY  - 2023//
TI  - Enrofloxacin poisoning: a rare occurrence in children
JO  - Indian journal of pediatrics
A1  - Senapati, Bibhas Chandra
A1  - Vyasam, Siva
A1  - Prasad, Shankar
A1  - Sekhar, Jerin C.
A1  - Angurana, Suresh Kumar
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - To the Editor: A 4-y-old male presented with accidental ingestion of syrup containing enrofloxacin (200 mg/mL), bromhexine, and 2-pyrrolidones, which was stored in a fruit juice bottle over the refrigerator in the household. Soon after ingestion, he developed vomiting, generalized tonic-clonic seizures, and altered sensorium. He was admitted to a nearby hospital where he underwent endotracheal intubation and mechanical ventilation, and received antiseizure medications (ASMs) before being referred to our center in view of persistent encephalopathy. He was noted to have a low Glasgow Coma Scale (6/15), hypotonia, and normal hemodynamic parameters, pupillary size and reaction, deep tendon reflexes, and the rest of the systemic examination. Management included mechanical ventilation, sedation-analgesia, intravenous fluids, and ASMs. Investigations revealed normal blood glucose, renal and liver functions, and electrocardiogram. There was improvement in his neurological status, and he was extubated after 72 h of ingestion. Extracorporeal removal of toxin (by plasma exchange or hemodialysis) was deferred in view of the time elapsed (36 h) beyond the half-life of enrofloxacin (26.6 ± 6 h), large volume of distribution (6.4 ± 1.2 L⁄kg), and the highly lipophilic nature of the drug [1]; and an improvement in clinical status. At discharge, he had a normal neurological status...<p />  <p>Language: en</p>
LA  - en
SN  - 0019-5456
UR  - http://dx.doi.org/10.1007/s12098-022-04450-3
ID  - ref1
ER  -