TY  - JOUR
PY  - 2023//
TI  - First episode psychosis with and without the use of cannabis and synthetic cannabinoids: psychopathology, global functioning and suicidal ideation and antipsychotic effectiveness
JO  - Psychiatry research
A1  - Ricci, Valerio
A1  - Ceci, Franca
A1  - Di Carlo, Francesco
A1  - Di Muzio, Ilenia
A1  - Ciavoni, Laura
A1  - Santangelo, Monica
A1  - Di Salvo, Gabriele
A1  - Pettorruso, Mauro
A1  - Martinotti, Giovanni
A1  - Maina, Giuseppe
SP  - e115053
EP  - e115053
VL  - 320
IS  - 
N2  - BACKGROUND: Natural Cannabis (NC) and Synthetic Cannabinoids (SCs) use can increase the risk of developing psychotic disorders and exacerbate their course. AIMS: To examine the differences between psychoses not associated with cannabis use and those associated with NC and SCs use, evaluating psychotic symptoms, global functioning, dissociative symptoms and suicidal ideation. <br><br>METHODS: The sample of 61 patients with First Episode Psychosis (FEP) was divided into 3 groups: non-Cannabis users (non-users, N = 20); NC users (THC-users, N = 21); SCs users (SPICE-users, N = 20). Each group was assessed at FEP and after 3 and 9 months through specific psychopathological scales. <br><br>RESULTS: THC-users, and even more SPICE-users, displayed much more severe positive symptoms than non-users. Negative symptoms were higher among non-users. After 9 months the non-users had recovered significantly better than SPICE-users in their global functioning. Dissociative symptoms were significantly greater in substance users. Finally, suicidal ideation was higher in SPICE-users than in both THC-users and non-users. <br><br>DISCUSSION: The psychoses induced by NC and SCs showed different symptomatic pictures and outcomes from each other and when compared to the psychoses not associated with the use of substances; such knowledge could be relevant in identifying a specific drug treatment.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2023.115053
ID  - ref1
ER  -