TY  - JOUR
PY  - 2023//
TI  - Incorporation of concussion history as part of the LIfestyle for BRAin Health (LIBRA) modifiable factors risk score and associations with cognition in older former National Football League players
JO  - Alzheimer's and dementia
A1  - Brett, Benjamin L.
A1  - Aggarwal, Neelum T.
A1  - Chandran, Avinash
A1  - Kerr, Zachary Yukio
A1  - Walton, Samuel R.
A1  - DeFreese, J. D.
A1  - Guskiewicz, Kevin M.
A1  - Echemendia, Ruben J.
A1  - Meehan, William P. 3rd
A1  - McCrea, Michael A.
A1  - Mannix, Rebekah
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: Investigate associations between the LIfestyle for BRAin Health (LIBRA) risk score with odds of mild cognitive impairment (MCI) diagnosis and cognitive function, incorporating concussion history. <br><br>METHODS: Former National Football League (NFL) players (N = 1050; mean age = 64.8 ± 9.0-years) completed initial testing for integration of concussion history into LIBRA scores (i.e., modified-LIBRA) and completed the Brief Test of Adult Cognition by Telephone (BTACT). Modified-LIBRA score (including concussion history) associations with odds of MCI and cognitive dysfunction were assessed via logistic and linear regression. <br><br>RESULTS: The highest quartile LIBRA scores were six times more likely to have a diagnosis of MCI compared to the lowest quartile (OR = 6.27[3.61, 10.91], p < 0.001). Modified-LIBRA scores significantly improved model fit for odds of MCI above original LIBRA scores (χ(2) (1) = 7.76, p = 0.005) and accounted for a greater fraction of variance in executive function (ΔR(2) = 0.02, p = 0.003) and episodic memory (ΔR(2)  = 0.02, p = 0.002). <br><br>CONCLUSIONS: Modified-LIBRA score, incorporating concussion history, may help monitoring risk status in former contact sport athletes, by targeting modifiable, lifestyle-related risk factors.<p />  <p>Language: en</p>
LA  - en
SN  - 1552-5260
UR  - http://dx.doi.org/10.1002/alz.12929
ID  - ref1
ER  -