TY  - JOUR
PY  - 2023//
TI  - Thrsp gene and the ADHD predominantly inattentive presentation
JO  - ACS chemical neuroscience
A1  - Custodio, Raly James Perez
A1  - Kim, Mikyung
A1  - Chung, Young-Chul
A1  - Kim, Bung-Nyun
A1  - Kim, Hee Jin
A1  - Cheong, Jae Hoon
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - There are three presentations of attention-deficit/hyperactivity disorder (ADHD): the predominantly inattention (ADHD-PI), predominantly hyperactive-impulsive (ADHD-HI), and combined (ADHD-C) presentations of ADHD. These may represent distinct childhood-onset neurobehavioral disorders with separate etiologies. ADHD diagnoses are behaviorally based, so investigations into potential etiologies should be founded on behavior. Animal models of ADHD demonstrate face, predictive, and construct validity when they accurately reproduce elements of the symptoms, etiology, biochemistry, and disorder treatment. Spontaneously hypertensive rats (SHR/NCrl) fulfill many validation criteria and compare well with clinical cases of ADHD-C. Compounding the difficulty of selecting an ideal model to study specific presentations of ADHD is a simple fact that our knowledge regarding ADHD neurobiology is insufficient. Accordingly, the current review has explored a potential animal model for a specific presentation, ADHD-PI, with acceptable face, predictive, and construct validity. The Thrsp gene could be a biomarker for ADHD-PI presentation, and THRSP OE mice could represent an animal model for studying this distinct ADHD presentation.<p />  <p>Language: en</p>
LA  - en
SN  - 1948-7193
UR  - http://dx.doi.org/10.1021/acschemneuro.2c00710
ID  - ref1
ER  -