TY  - JOUR
PY  - 2023//
TI  - Are bipolar disorder, major depression, and suicidality linked with Toxoplasma gondii? A seromolecular case-control study
JO  - Postgraduate medicine
A1  - Demirel, Ömer Faruk
A1  - Akgül, Özer
A1  - Bulu, Ersel
A1  - Tanriöver Aydin, Ezgi
A1  - Uysal Cesur, Nuray
A1  - Aksoy Poyraz, Cana
A1  - Oner, Yasar Ali
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: The existence of predisposing effects of latent Toxoplasma gondii (T. gondii) infection in bipolar disorder (BD), major depression (MD), and even suicide attempt (SA) has long been debatable. This conjecture remains unclear because there is a lack of evidence regarding how T. gondii manipulates the brain and behavior. <br><br>METHODS: We investigated the influence of T. gondii infection on BD and MD patients with or without SA compared to age-, sex-, and province-matched healthy controls (HCs) concurrently with serology and molecular-based evaluations. We prospectively assessed 147 volunteers with BD, 161 with MD, and 310 HCs. <br><br>RESULTS: T. gondii seropositivity rates were 57.1% for BD, 29.2% for MD, 64.8% for SA, and 21.3% for HC. Binary logistic regression analyses revealed that T. gondii positive Immunoglobulin G (IgG) status may be a prominent tendentious agent for BD (OR = 3.52; 95% CI [2.19-5.80]; p < 0.001) and SA (OR = 17.17; 95% CI [8.12-36.28]; p < 0.001), but not for MD (OR = 1.21; 95% CI [0.74-1.99]; p = 0.45). Nevertheless, the T. gondii DNA ratios determined by polymerase chain reaction (PCR) were linked to BD and MD. <br><br>CONCLUSION: Our findings strongly support the burgeoning interest in the possibility that latent T. gondii infection may be relevant to the etiology of BD and SA, although this connection remains ambiguous.<p />  <p>Language: en</p>
LA  - en
SN  - 0032-5481
UR  - http://dx.doi.org/10.1080/00325481.2023.2176042
ID  - ref1
ER  -