TY  - JOUR
PY  - 2023//
TI  - The role of transcranial magnetic stimulation in treating depression after traumatic brain injury
JO  - Brain stimulation
A1  - Olsson, Sofia Eva
A1  - Singh, Harpreet
A1  - Kerr, Marcel Satsky
A1  - Podlesh, Zachary
A1  - Chung, Jacline
A1  - Tjan, Amanda
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Traumatic brain injury (TBI) is defined as the brain dysfunction occurring after an individual sustains trauma to the cerebrum. Various incidents may cause TBI, such as motor vehicle accidents (MVA), sports injuries, or violent events. Depending on the location and severity of impact, patients may experience relatively mild, to severe, lifelong symptoms. The presence of symptoms following TBI may be diagnosed as post-concussion syndrome (PCS). Many patients have acute depression symptoms after TBI which persist as medication refractory post-concussion depression. TBI survivors are at increased life-time risk of developing pharmaco-resistant major depressive disorder, bipolar disorder, dysthymia, or other psychiatric disorders along with increased risk of seizures.     Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive, outpatient therapy that is FDA approved to treat major depressive disorder (MDD). Whereas rTMS therapy has been growing in the field of psychiatry, there is limited research on the use of rTMS for treatment of neurological issues, such as post-concussion syndrome.     Low-frequency right-sided rTMS, an inhibitory protocol, has demonstrated a mild, positive impact on TBI-related depression. To our knowledge, the current study is the first to assess excitatory rTMS of the left dorsolateral prefrontal cortex as a treatment for depression in individuals who experienced TBI and PCS. We hypothesize that the rTMS protocol will significantly improve depression symptoms in patients.<p />  <p>Language: en</p>
LA  - en
SN  - 1935-861X
UR  - http://dx.doi.org/10.1016/j.brs.2023.02.005
ID  - ref1
ER  -