TY  - JOUR
PY  - 2023//
TI  - Childhood maltreatment and DNA methylation: a systematic review
JO  - Neuroscience and biobehavioral reviews
A1  - Rubens, Mackenzie
A1  - Bruenig, Dagmar
A1  - Adams, Jessica A. M.
A1  - Suresh, Shruthi M.
A1  - Sathyanarayanan, Anita
A1  - Haslam, Divna
A1  - Shenk, Chad E.
A1  - Mathews, Ben
A1  - Mehta, Divya
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Child maltreatment (CM) encompasses sexual abuse, physical abuse, emotional abuse, neglect, and exposure to domestic and family violence. Epigenetic research investigating CM has focused on differential DNA methylation (DNAm) in genes associated with the stress response, but there has been limited evaluation of the specific effects of subtypes of CM. This systematic review of literature investigating DNAm associated with CM in non-clinical populations aimed to summarise the approaches currently used in research, how the type of maltreatment and age of exposure were encoded via methylation, and which genes have consistently been associated with CM. A total of fifty-four papers were eligible for review, including forty-one candidate gene studies, eight epigenome-wide association studies, and five studies with a mixed design. The ways in which the various forms of CM were conceptualised and measured varied between papers. Future studies would benefit from assessments that employ conceptually robust definitions of CM, and that capture important contextual information such as age of exposure and subtype of CM.<p />  <p>Language: en</p>
LA  - en
SN  - 0149-7634
UR  - http://dx.doi.org/10.1016/j.neubiorev.2023.105079
ID  - ref1
ER  -