TY  - JOUR
PY  - 2023//
TI  - In vivo serotonin transporter and 1A receptor binding potential and ecological momentary assessment (EMA) of stress in major depression and suicidal behavior
JO  - European Neuropsychopharmacology
A1  - Bartlett, Elizabeth A.
A1  - Zanderigo, Francesca
A1  - Stanley, Barbara
A1  - Choo, Tse-Hwei
A1  - Galfalvy, Hanga C.
A1  - Pantazatos, Spiro P.
A1  - Sublette, M. Elizabeth
A1  - Miller, Jeffrey M.
A1  - Oquendo, Maria A.
A1  - Mann, J. John
SP  - 1
EP  - 13
VL  - 70
IS  - 
N2  - We examined relationships between the serotonin system and stress in major depression and suicidal behavior. Twenty-five medication-free depressed participants (13 suicide attempters) underwent same-day [(11)C]DASB and [(11)C]CUMI-101 positron emission tomography (PET) imaging. Binding potential (BP(ND)) to the serotonin transporter (5-HTT) and serotonin 1A (5-HT(1A)) receptor, respectively, was quantified using the NRU 5-HT atlas, reflecting distinct spatial distributions of multiple serotonin targets. Ecological momentary assessment (EMA) measured current stress over one week proximal to imaging. EMA stress did not differ between attempters and non-attempters. In all depressed participants, 5-HTT and 5-HT(1A) BP(ND) were unrelated to EMA stress. There were region-specific effects of 5-HTT (p=0.002) and 5-HT(1A) BP(ND) (p=0.03) in attempters vs. nonattempters. In attempters, region-specific associations between 5-HTT (p=0.03) and 5-HT(1A) (p=0.005) BP(ND) and EMA stress emerged. While no post-hoc 5-HTT BP(ND) correlations were significant, 5-HT(1A) BP(ND) correlated positively with EMA stress in attempters in 9/10 regions (p-values<0.007), including the entire cortex except the largely occipital region 5. Brodmann-based regional analyses found diminished effects for 5-HTT and subcortically localized positive corrrelations between 5-HT(1A) and EMA stress, in attempters only. Given comparable depression severity and childhood and current stress between attempters and nonattempters, lower 5-HTT binding in attempters vs. nonattempters may suggest a biological risk marker. Localized lower 5-HTT and widespread higher 5-HT(1A) binding with stress among attempters specifically may suggest that a serotonergic phenotype might be a key determinant of risk or resiliency for suicidal behavior.<p />  <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/10.1016/j.euroneuro.2023.01.006
ID  - ref1
ER  -