TY  - JOUR
PY  - 2023//
TI  - Childhood trauma and self-harm in youths with bipolar disorders
JO  - Current neuropharmacology
A1  - Janiri, Delfina
A1  - Di Luzio, Michelangelo
A1  - Montanari, Silvia
A1  - Hirsch, Daniele
A1  - Simonetti, Alessio
A1  - Moccia, Lorenzo
A1  - Conte, Eliana
A1  - Contaldo, Ilaria
A1  - Veredice, Chiara
A1  - Mercuri, Eugenio
A1  - Sani, Gabriele
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Bipolar disorders (BD) in youth are associated with high risk of self-harm behaviors. Childhood trauma (CT) is a relevant environmental stressor that is related with both BD diagnosis and self-harm in adulthood. It is not yet established whether CT may impact on self-harm risk in youth. Therefore, the aim of this study was to investigate the distribution patterns of CT in youth BD with and without self-harm. <br><br>METHODS: We assessed 273 participants (aged 13-25 years), 96 youths with BD according to DSM-5 criteria and 177 healthy controls (HC). History of CT was obtained using the Childhood Trauma Questionnaire (CTQ). The association between CT and self-harm was tested using multivariate statistical models. <br><br>RESULTS: Over 45% of participants with BD reported lifetime self-harm. The BD Self-harm group reported more emotional abuse, emotional neglect, sexual abuse, and physical abuse than HC. The BD No-Self-harm group reported more emotional abuse than HC. The BD Self-harm group reported more emotional abuse and neglect than the BD No-Self-harm group, The BD Self-harm group also reported more separated parents, hospitalizations, smoking, use of antiepileptics, antipsychotics and lithium. Emotional abuse was an independent predictor of self-harm in youths with BD. <br><br>CONCLUSIONS: Findings support the importance of assessing CT, in particular emotional abuse, in youth with BD at risk for self-harm.<p />  <p>Language: en</p>
LA  - en
SN  - 1570-159X
UR  - http://dx.doi.org/10.2174/1570159X21666230213155249
ID  - ref1
ER  -