TY  - JOUR
PY  - 2023//
TI  - History of suicide attempt associated with amygdala and hippocampus changes among individuals with schizophrenia
JO  - European archives of psychiatry and clinical neuroscience
A1  - Yin, Yi
A1  - Tong, Jinghui
A1  - Huang, Junchao
A1  - Wang, Leilei
A1  - Tian, Baopeng
A1  - Chen, Song
A1  - Tan, Shuping
A1  - Wang, Zhiren
A1  - Yu, Ting
A1  - Li, Yanli
A1  - Tong, Yongsheng
A1  - Fan, Fengmei
A1  - Kochunov, Peter
A1  - Hong, L. Elliot
A1  - Tan, Yunlong
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Abnormalities in subcortical brain structures may reflect higher suicide risk in mood disorders, but less is known about its associations for schizophrenia. This cross-sectional imaging study aimed to explore whether the history of suicide attempts was associated with subcortical changes among individuals with schizophrenia. We recruited 44 individuals with schizophrenia and a history of suicide attempts (SZ-SA) and 44 individuals with schizophrenia but without a history of suicide attempts (SZ-NSA) and 44 healthy controls. Linear regression showed that SZ-SA had smaller volumes of the hippocampus (Cohen's d = -0.72), the amygdala (Cohen's d = -0.69), and some nuclei of the amygdala (Cohen's d, -0.57 to -0.72) than SZ-NSA after adjusting for age, sex, illness phase, and intracranial volume. There was no difference in the volume of the subfields of the hippocampus. It suggests the history of suicide attempts is associated with subcortical volume alterations in schizophrenia.<p />  <p>Language: en</p>
LA  - en
SN  - 0940-1334
UR  - http://dx.doi.org/10.1007/s00406-023-01554-5
ID  - ref1
ER  -