TY  - JOUR
PY  - 2023//
TI  - Grip strength, gait speed, and trajectories of cognitive function in community-dwelling older adults: a prospective study
JO  - Alzheimer's and dementia: diagnosis, assessment and disease monitoring
A1  - Wu, Zimu
A1  - Woods, Robyn L.
A1  - Chong, Trevor T.-J.
A1  - Orchard, Suzanne G.
A1  - Shah, Raj C.
A1  - Wolfe, Rory
A1  - Storey, Elsdon
A1  - Sheets, Kerry M.
A1  - Murray, Anne M.
A1  - McNeil, John J.
A1  - Ryan, Joanne
SP  - e12388
EP  - e12388
VL  - 15
IS  - 1
N2  - INTRODUCTION: This study investigated whether grip strength and gait speed predict cognitive aging trajectories and examined potential sex-specific associations. <br><br>METHODS: Community-dwelling older adults (n = 19,114) were followed for up to 7 years, with regular assessment of global function, episodic memory, psychomotor speed, and executive function. Group-based multi-trajectory modeling identified joint cognitive trajectories. Multinomial logistic regression examined the association of grip strength and gait speed at baseline with cognitive trajectories. <br><br>RESULTS: High performers (14.3%, n = 2298) and low performers (4.0%, n = 642) were compared to the average performers (21.8%, n = 3492). Grip strength and gait speed were positively associated with high performance and negatively with low performance (P-values < 0.01). The association between grip strength and high performance was stronger in women (interaction P < 0.001), while gait speed was a stronger predictor of low performance in men (interaction P < 0.05). <br><br>DISCUSSION: Grip strength and gait speed are associated with cognitive trajectories in older age, but with sex differences. HIGHLIGHTS: There is inter-individual variability in late-life cognitive trajectories.Grip strength and gait speed predicted cognitive trajectories in older age.However, sex-specific associations were identified.In women, grip strength strongly predicted high, compared to average, trajectory.In men, gait speed was a stronger predictor of low cognitive performance trajectory.<p />  <p>Language: en</p>
LA  - en
SN  - 2352-8729
UR  - http://dx.doi.org/10.1002/dad2.12388
ID  - ref1
ER  -