TY  - JOUR
PY  - 2023//
TI  - Effect of levodopa and environmental setting on gait and turning digital markers related to falls in people with Parkinson's disease
JO  - Movement disorders clinical practice
A1  - Shah, Vrutangkumar V.
A1  - McNames, James
A1  - Carlson-Kuhta, Patricia
A1  - Nutt, John G.
A1  - El-Gohary, Mahmoud
A1  - Sowalsky, Kristen
A1  - Mancini, Martina
A1  - Horak, Fay B.
SP  - 223
EP  - 230
VL  - 10
IS  - 2
N2  - BACKGROUND: It is unknown whether medication status (off and on levodopa) or laboratory versus home settings plays a role in discriminating fallers and non-fallers in people with Parkinson's disease (PD). <br><br>OBJECTIVES: To investigate which specific digital gait and turning measures, obtained with body-worn sensors, best discriminated fallers from non-fallers with PD in the clinic and during daily life. <br><br>METHODS: We recruited 34 subjects with PD (17 fallers and 17 non-fallers based on the past 6 month's falls). Subjects wore three inertial sensors attached to both feet and the lumbar region in the laboratory for a 3-minute walking task (both off and on levodopa) and during daily life activities for a week. We derived 24 digital (18 gait and 6 turn) measures from the 3-minute walk and from daily life. <br><br>RESULTS: In clinic, none of the gait and turning measures collected during on levodopa state were significantly different between fallers and non-fallers. In contrast, digital measures collected in the off levodopa state were significantly different between groups, (average turn velocity, average number of steps to complete a turn, and variability of gait speed, P < 0.03). During daily life, the variability of average turn velocity (P = 0.023) was significantly different in fallers than non-fallers. Last, the average number of steps to complete a turn was significantly correlated with the patient-reported outcomes. <br><br>CONCLUSIONS: Digital measures of turning, but not gait, were different in fallers compared to non-fallers with PD, in the laboratory when off medication and during a daily life.<p />  <p>Language: en</p>
LA  - en
SN  - 2330-1619
UR  - http://dx.doi.org/10.1002/mdc3.13601
ID  - ref1
ER  -