TY  - JOUR
PY  - 2023//
TI  - Thyroid hormone abuse among elite athletes
JO  - Journal of the Endocrine Society
A1  - Handelsman, David J.
A1  - Gild, Matti
A1  - Clifton-Bligh, Roderick
A1  - Speers, Naomi
A1  - Kouzios, Dorothy
A1  - McMartin, Melissa C.
A1  - Desai, Reena
SP  - bvad027
EP  - bvad027
VL  - 7
IS  - 5
N2  - CONTEXT: Thyroid hormone (TH) abuse for performance enhancement in sport remains controversial and it is not prohibited in sports under the World Anti-Doping Code. However, the prevalence of TH usage in athletes is not known. <br><br>OBJECTIVE: We investigated TH use among Australian athletes undergoing antidoping tests for competition in World Anti-Doping Agency (WADA)-compliant sports by measuring TH in serum and surveying mandatory doping control form (DCF) declarations by athletes of all drugs used in the week prior to the antidoping test. <br><br>METHODS: Serum thyroxine (T4), triiodothyronine (T3), and reverse T3 were measured by liquid chromatography-mass spectrometry and serum thyrotropin, free T4, and free T3 by immunoassays in 498 frozen serum samples from antidoping tests together with a separate set of 509 DCFs. <br><br>RESULTS: Two athletes had biochemical thyrotoxicosis giving a prevalence of 4 per 1000 athletes (upper 95% confidence limit [CL] 16). Similarly, only 2 of 509 DCFs declared usage of T4 and none for T3, also giving a prevalence of 4 (upper 95% CL 16) per 1000 athletes. These estimates were consistent with DCF analyses from international competitions and lower than the estimated T4 prescription rates in the age-matched Australian population. <br><br>CONCLUSION: There is minimal evidence for TH abuse among Australian athletes being tested for competing in WADA-compliant sports.<p />  <p>Language: en</p>
LA  - en
SN  - 2472-1972
UR  - http://dx.doi.org/10.1210/jendso/bvad027
ID  - ref1
ER  -