TY  - JOUR
PY  - 2002//
TI  - Is there a genetic relationship between alcoholism and depression?
JO  - Alcohol research and health
A1  - Nurnberger, J. I. Jr
A1  - Foroud, Tatiana
A1  - Flury, Leah
A1  - Meyer, Eric T.
A1  - Wiegand, Ryan
SP  - 233
EP  - 240
VL  - 26
IS  - 3
N2  - The Collaborative Study on the Genetics of Alcoholism (COGA) seeks to identify genes contributing to alcoholism and related traits (i.e., phenotypes), including depression. Among alcoholic subjects the COGA study found an increased prevalence of depressive syndrome (i.e., depression that may or may not occur in conjunction with increased drinking). This combination of alcoholism and depression tends to run in families. Comorbid alcoholism and depression occurred substantially more often in first-degree relatives of COGA participants with alcoholism than in relatives of control participants. Based on these data, COGA investigators defined three phenotypes--"alcoholism," "alcoholism and depression," and "alcoholism or depression"--and analyzed whether these phenotypes were linked to specific chromosomal regions. These analyses found that the "alcoholism or depression" phenotype showed significant evidence for genetic linkage to an area on chromosome 1. This suggests that a gene or genes on chromosome 1 may predispose some people to alcoholism and others to depression (which may be alcohol induced).<p />  <p>Language: en</p>
LA  - en
SN  - 1535-7414
UR  - http://dx.doi.org/
ID  - ref1
ER  -