TY  - JOUR
PY  - 2023//
TI  - Cortical thinning in male obstructive sleep apnoea patients with excessive daytime sleepiness
JO  - Frontiers in neurology
A1  - Li, Yezhou
A1  - Wang, Jing
A1  - Ji, Lirong
A1  - Cheng, Chaohong
A1  - Su, Tong
A1  - Wu, Shuqing
A1  - Han, Fei
A1  - Cox, Daniel J.
A1  - Wang, Erlei
A1  - Chen, Rui
SP  - e1019457
EP  - e1019457
VL  - 14
IS  - 
N2  - BACKGROUND AND PURPOSE: Obstructive sleep apnoea is associated with excessive daytime sleepiness due to sleep fragmentation and hypoxemia, both of which can lead to abnormal brain morphology. However, the pattern of brain structural changes associated with excessive daytime sleepiness is still unclear. This study aims to investigate the effects of excessive daytime sleepiness on cortical thickness in patients with obstructive sleep apnoea. <br><br>MATERIALS AND METHODS: 61 male patients with newly diagnosed obstructive sleep apnoea were included in the present study. Polysomnography and structural MRI were performed for each participant. Subjective daytime sleepiness was assessed using the Epworth Sleepiness Scale score. Surface-based morphometric analysis was performed using Statistical Parametric Mapping 12 and Computational Anatomy 12 toolboxes to extract cortical thickness. <br><br>RESULTS: Using the median Epworth Sleepiness Scale score, patients were divided into the non-sleepiness group and the sleepiness group. The cortical thickness was markedly thinner in the sleepiness group in the left temporal, frontal, and parietal lobe and bilateral pre- and postcentral gyri (pFWE < 0.05). There was a significant negative correlation between the cortical thickness and the Epworth Sleepiness Scale score. After adjusting for age, body mass index, and obstructive sleep apnoea severity, the Epworth Sleepiness Scale score remained an independent factor affecting the cortical thickness of the left middle temporal lobe, transverse temporal and temporal pole. <br><br>CONCLUSION: Subjective daytime sleepiness is associated with decreased cortical thickness, and the Epworth Sleepiness Scale score may be of utility as a clinical marker of brain injury in patients with obstructive sleep apnoea.<p />  <p>Language: en</p>
LA  - en
SN  - 1664-2295
UR  - http://dx.doi.org/10.3389/fneur.2023.1019457
ID  - ref1
ER  -