TY  - JOUR
PY  - 2023//
TI  - Exploring the association of addiction-related genetic factors with non-suicidal self-injury in adolescents
JO  - Frontiers in psychiatry
A1  - Guo, Zhichao
A1  - Liu, Yilin
A1  - Wang, Chengjuan
A1  - Li, Shujun
A1  - Yu, Lei
A1  - Wu, Wenzhi
A1  - You, Xu
A1  - Zhang, Yunqiao
A1  - Teng, Zhaowei
A1  - Zeng, Yong
SP  - e1126615
EP  - e1126615
VL  - 14
IS  - 
N2  - BACKGROUND: Non-suicidal self-injury (NSSI) is self-injurious behavior without suicidal intent commonly seen in the adolescent population and poses a serious threat to the life safety of adolescents. Related researches suggest a possible correlation between addiction and the occurrence of NSSI. This study aimed to explore the correlation between addiction and NSSI from a molecular biological perspective by analyzing the differential expression of addiction-related genes in NSSI patients. <br><br>METHODS: (1) The association between addiction and non-suicidal self-injury in a Chinese adolescent population was verified with the help of questionnaires on substance and non-substance addictions and non-suicidal self-injury among 1,329 adolescents in China, (2) Screening for key genes associated with addiction by bioinformatics analysis, and (3) RT-qPCR experiment was performed to validate key genes and Receiver Operating Characteristic curves were plotted for target genes. <br><br>RESULTS: (1) Substance and non-substance addictions were all significantly correlated with non-suicidal self-injury, (2) Four target genes: SERPINA3, SLC14A1, RPS6 and RPS3A were screened by bioinformatics technique, and (3) Relative quantitative analysis by RT-qPCR revealed that the expression levels of SLC14A1 (p < 0.01), RPS6 (p < 0.05) and RPS3A (p < 0.01) were significantly higher in NSSI patients than in healthy controls. <br><br>CONCLUSION: (1) The significant association between addiction and NSSI exists in the Chinese adolescent population and (2) Addiction-related genes SLC14A1, RPS6, and RPS3A are differentially expressed in adolescents with NSSI. The genes have the potential to become biological markers for the diagnosis of NSSI.<p />  <p>Language: en</p>
LA  - en
SN  - 1664-0640
UR  - http://dx.doi.org/10.3389/fpsyt.2023.1126615
ID  - ref1
ER  -