TY  - JOUR
PY  - 2023//
TI  - Influence of cannabis use on incidence of psychosis in people at clinical high risk
JO  - Psychiatry and the Clinical Neurosciences
A1  - Chester, Lucy A.
A1  - Valmaggia, Lucia R.
A1  - Kempton, Matthew J.
A1  - Chesney, Edward
A1  - Oliver, Dominic
A1  - Hedges, Emily P.
A1  - Klatsa, Elise
A1  - Stahl, Daniel
A1  - van der Gaag, Mark
A1  - de Haan, Lieuwe
A1  - Nelson, Barnaby
A1  - McGorry, Patrick
A1  - Amminger, G. Paul
A1  - Riecher-Rössler, Anita
A1  - Studerus, Erich
A1  - Bressan, Rodrigo
A1  - Barrantes-Vidal, Neus
A1  - Krebs, Marie-Odile
A1  - Glenthøj, Birte
A1  - Nordentoft, Merete
A1  - Ruhrmann, Stephan
A1  - Sachs, Gabriele
A1  - McGuire, Philip
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - AIMS: Evidence for case-control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of psychosis. Secondary aims were to assess associations between cannabis use and the persistence of psychotic symptoms, and with functional outcome. <br><br>METHODS: Current and previous cannabis use were assessed in individuals at clinical high risk of psychosis (n=334) and healthy controls (n=67), using a modified version of the Cannabis Experience Questionnaire. Participants were assessed at baseline and followed up for 2 years. Transition to psychosis and persistence of psychotic symptoms were assessed using the Comprehensive Assessment of At-Risk Mental States criteria. Level of functioning at follow up was assessed using the Global Assessment of Functioning disability scale. <br><br>RESULTS: During follow up, 16.2% of the clinical high-risk sample developed psychosis. Of those who did not become psychotic, 51.4% had persistent symptoms and 48.6% were in remission. There was no significant association between any measure of cannabis use at baseline and either transition to psychosis, the persistence of symptoms, or functional outcome. <br><br>CONCLUSIONS: These findings contrast with epidemiological data that suggest that cannabis use increases the risk of psychotic disorder. This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1323-1316
UR  - http://dx.doi.org/10.1111/pcn.13555
ID  - ref1
ER  -