TY  - JOUR
PY  - 2023//
TI  - Association between percutaneous oxygen saturation and mortality of patients with mild traumatic brain injury at ICU admission: an analysis of the MIMIC-III database
JO  - Advances in therapy
A1  - Sun, Wei
A1  - Wang, Ling
A1  - Yuan, Shiqi
A1  - Liu, Rongrong
A1  - Song, Pingping
A1  - Che, Wenqiang
A1  - Xu, Jiamin
A1  - Lyu, Jun
A1  - Zhang, Yusheng
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - INTRODUCTION: Research related to the result of patients with mild traumatic brain injury and the role of percutaneous oxygen saturation (SpO2) level is rarely reported. Our study investigated the relationship between SpO2 and the 30- and 90-day mortality among patients with mild TBI. <br><br>METHODS: A total of 1027 patients with mild TBI [Glasgow Coma Scale (GCS) > 12] were enrolled from the Medical Information Mart for Intensive Care (MIMIC-III) database. The patients were classified into low-SpO2 (< 95%), moderate-SpO2 (95-98%), and high-SpO2 groups (> 98%). With 30- and 90-day mortality rates as the main outcomes, Cox regression and confined cubic spline models were adopted. <br><br>RESULTS: There was a U-shaped curve in confined cubic splines for the relationship between SpO2 and mortality. Compared with the moderate-SpO2 group, the high-SpO2 group exhibited a much higher risk of mortality after modification, with hazard proportions of 2.108 (95% CI 1.211-3.670, P < 0.05) for the 30-day mortality and 1.760 (95% CI 1.140-2.720, P < 0.05) for the 90-day mortality, and the low-SpO2 group exhibited a much higher risk of mortality after modification, with hazard proportions of 2.215 (95% CI 1.194-4.110, P < 0.05) for the 90-day mortality. <br><br>CONCLUSION: Among patients with mild TBI, the correlation between SpO2 level and 30- and 90-day mortality followed a U-shaped curve. Both low and high SpO2 level exerted potential harmful effects on the outcomes of patients with mild TBI. The SpO2 range of 95-98% could be the optimal SpO2 level for mild patients with TBI.<p />  <p>Language: en</p>
LA  - en
SN  - 0741-238X
UR  - http://dx.doi.org/10.1007/s12325-023-02499-w
ID  - ref1
ER  -