TY  - JOUR
PY  - 2023//
TI  - Cerebral blood flow in children with persisting postconcussive symptoms and posttraumatic headache at 2 weeks postconcussion
JO  - Journal of neurosurgery. Pediatrics.
A1  - Fan, Feiven
A1  - Beare, Richard
A1  - Takagi, Michael
A1  - Anderson, Nicholas
A1  - Bressan, Silvia
A1  - Clarke, Cathriona J.
A1  - Davis, Gavin A.
A1  - Dunne, Kevin
A1  - Fabiano, Fabian
A1  - Hearps, Stephen J. C.
A1  - Ignjatovic, Vera
A1  - Parkin, Georgia
A1  - Rausa, Vanessa C.
A1  - Seal, Marc
A1  - Shapiro, Jesse S.
A1  - Babl, Franz E.
A1  - Anderson, Vicki
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: Persisting postconcussive symptoms (pPCS), particularly headache, can significantly disrupt children's recovery and functioning. However, the underlying pathophysiology of these symptoms remains unclear. The goal in this study was to determine whether pPCS are related to cerebral blood flow (CBF) at 2 weeks postconcussion. The authors also investigated whether variations in CBF can explain the increased risk of acute posttraumatic headache (PTH) in female children following concussion. <br><br>METHODS: As part of a prospective, longitudinal study, the authors recruited children 5-18 years old who were admitted to the emergency department of a tertiary pediatric hospital with a concussion sustained within 48 hours of admission. Participants underwent pseudocontinuous arterial spin labeling MRI at 2 weeks postconcussion to quantify global mean gray and white matter perfusion (in ml/100 g/min). Conventional frequentist analysis and Bayesian analysis were performed. <br><br>RESULTS: Comparison of recovered (n = 26) and symptomatic (n = 12) groups (mean age 13.15 years, SD 2.69 years; 28 male) found no differences in mean global gray and white matter perfusion at 2 weeks postconcussion (Bayes factors > 3). Although female sex was identified as a risk factor for PTH with migraine features (p = 0.003), there was no difference in CBF between female children with and without PTH. <br><br>CONCLUSIONS: Global CBF was not associated with pPCS and female PTH at 2 weeks after pediatric concussion. These findings provide evidence against the use of CBF measured by arterial spin labeling as an acute biomarker for pediatric concussion recovery.<p />  <p>Language: en</p>
LA  - en
SN  - 1933-0707
UR  - http://dx.doi.org/10.3171/2023.3.PEDS2339
ID  - ref1
ER  -