TY  - JOUR
PY  - 2023//
TI  - Probing the association between cognition, suicidal behavior and tryptophan metabolism in a sample of individuals living with bipolar disorder: a secondary analysis
JO  - Brain sciences
A1  - Arru, Laura
A1  - Guiso, Beatrice
A1  - Garzilli, Mario
A1  - Congiu, Donatella
A1  - Bertazzo, Antonella
A1  - Manchia, Mirko
A1  - Comai, Stefano
A1  - Carpiniello, Bernardo
A1  - Pinna, Federica
A1  - Corrias, Carolina
A1  - Nasini, Sofia
A1  - Sut, Stefania
A1  - Dall'Acqua, Stefano
A1  - Meloni, Anna
A1  - Pisanu, Claudia
A1  - Squassina, Alessio
A1  - Paribello, Pasquale
A1  - Somaini, Giulia
A1  - Pinna, Ilaria
A1  - Iaselli, Maria Novella
A1  - Pulcinelli, Vittoria
A1  - Suprani, Federico
SP  - 
EP  - 
VL  - 13
IS  - 4
N2  - Background and Objectives: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <br><br>MATERIALS AND METHODS: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <br><br>RESULTS: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <br><br>CONCLUSIONS: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association.<p />  <p>Language: en</p>
LA  - en
SN  - 2076-3425
UR  - http://dx.doi.org/10.3390/brainsci13040693
ID  - ref1
ER  -