TY  - JOUR
PY  - 2023//
TI  - Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours
JO  - Elife
A1  - Venetucci Gouveia, Flavia
A1  - Germann, Jürgen
A1  - Elias, Gavin J. B.
A1  - Boutet, Alexandre
A1  - Loh, Aaron
A1  - Lopez Rios, Adriana Lucia
A1  - Torres Diaz, Cristina
A1  - Contreras Lopez, William Omar
A1  - Martinez, Raquel Chacon Ruiz
A1  - Fonoff, Erich Talamoni
A1  - Benedetti-Isaac, Juan Carlos
A1  - Giacobbe, Peter
A1  - Arango Pava, Pablo M.
A1  - Yan, Han
A1  - Ibrahim, George M.
A1  - Lipsman, Nir
A1  - Lozano, Andres
A1  - Hamani, Clement
SP  - e84566
EP  - e84566
VL  - 12
IS  - 
N2  - Deep brain stimulation targeting the posterior hypothalamus (pHyp-DBS) is being investigated as a treatment for refractory aggressive behaviour, but its mechanisms of action remain elusive. We conducted an integrated imaging analysis of a large multi-centre dataset, incorporating the volume of activated tissue modelling, probabilistic mapping, normative connectomics, and atlas-derived transcriptomics. Ninety-one percent of the patients responded positively to treatment, with a more striking improvement recorded in the pediatric population. Probabilistic mapping revealed an optimized surgical target within the posterior-inferior-lateral region of the posterior hypothalamic area. Normative connectomic analyses identified fibre tracts and interconnected brain areas associated with sensorimotor function, emotional regulation, and monoamine production. Functional connectivity between the target, periaqueductal gray and key limbic areas - together with patient age - were highly predictive of treatment outcome. Transcriptomic analysis showed that genes involved in mechanisms of aggressive behaviour, neuronal communication, plasticity and neuroinflammation might underlie this functional network.<p />  <p>Language: en</p>
LA  - en
SN  - 2050-084X
UR  - http://dx.doi.org/10.7554/eLife.84566
ID  - ref1
ER  -