TY  - JOUR
PY  - 2023//
TI  - Case report: Fatal poisoning caused by additive effects of two barbiturates
JO  - Frontiers in pharmacology
A1  - Takei, Sella
A1  - Kinoshita, Hiroshi
A1  - Jamal, Mostofa
A1  - Kumihashi, Mitsuru
A1  - Yamashita, Tadayoshi
A1  - Tanaka, Etsuko
A1  - Kawahara, Sachiko
A1  - Abe, Hiroko
A1  - Tsutsui, Kunihiko
A1  - Kimura, Shoji
SP  - e1196565
EP  - e1196565
VL  - 14
IS  - 
N2  - A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 and 0.22 μg/ml, respectively. We concluded that the death was due to the additive effects of two barbiturates. As both pentobarbital and phenobarbital act on gamma-aminobutyric acid (GABA) receptors, central nervous system activity was suppressed, causing respiratory depression. Additive pharmacological effects should be considered in cases of massive ingestion of multiple drugs.<p />  <p>Language: en</p>
LA  - en
SN  - 1663-9812
UR  - http://dx.doi.org/10.3389/fphar.2023.1196565
ID  - ref1
ER  -