TY  - JOUR
PY  - 2023//
TI  - Sex dimorphism in outcome of trauma patients presenting with severe shock: a multicenter cohort study
JO  - Journal of clinical medicine
A1  - van Wonderen, Stefan F.
A1  - Pape, Merel
A1  - Zuidema, Wietse P.
A1  - Edwards, Michael J. R.
A1  - Verhofstad, Michael H. J.
A1  - Tromp, Tjarda N.
A1  - Van Lieshout, Esther M. M.
A1  - Bloemers, Frank W.
A1  - Geeraedts, Leo M. G. Jr
SP  - 
EP  - 
VL  - 12
IS  - 11
N2  - BACKGROUND: The objective of this study was to determine the association between sex and outcome among severely injured patients who were admitted in severe shock. <br><br>METHODS: A retrospective multicenter study was performed in trauma patients (Injury Severity Score (ISS) ≥ 16) aged ≥ 16 presenting with severe shock (Shock Index > 1.3) over a 4-year period. To determine if sex was associated with mortality, Intensive Care Unit (ICU) admission, mechanical ventilation, blood transfusion and in-hospital complications, multivariable logistic regressions were performed. <br><br>RESULTS: In total, 189 patients were admitted to the Emergency Department in severe shock. Multivariable logistic regression analysis showed that female sex was independently associated with a decreased likelihood of acute kidney injury (OR 0.184; 95% CI 0.041-0.823; p = 0.041) compared to the male sex. A significant association between female sex and mortality, ICU admission, mechanical ventilation, other complications and packed red blood cells transfusion after admission could not be confirmed. <br><br>CONCLUSION: Female trauma patients in severe shock were significantly less likely to develop AKI during hospital stay. These results could suggest that female trauma patients may manifest a better-preserved physiologic response to severe shock when compared to their male counterparts. Prospective studies with a larger study population are warranted.<p />  <p>Language: en</p>
LA  - en
SN  - 2077-0383
UR  - http://dx.doi.org/10.3390/jcm12113701
ID  - ref1
ER  -