TY  - JOUR
PY  - 2023//
TI  - Event-related potential markers of suicidality in adolescents
JO  - International journal of neuropsychopharmacology
A1  - Doruk Camsari, Deniz
A1  - Lewis, Charles P.
A1  - Sonmez, Ayse Irem
A1  - Ozger, Can
A1  - Fatih, Parmis
A1  - Yuruk, Deniz
A1  - Shekunov, Julia
A1  - Vande Voort, Jennifer L.
A1  - Croarkin, Paul E.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Implicit cognitive markers may assist with the prediction of suicidality beyond clinical risk factors. The aim of this study was to investigate neural correlates associated with Death/Suicide Implicit Association Test (DS-IAT) via event-related potentials (ERP) in suicidal adolescents. <br><br>METHODS: Thirty inpatient adolescents with suicidal ideations and behaviors (SIBS), and thirty healthy controls from community were recruited. All participants underwent 64-channel electroencephalography, DS-IAT, and clinical assessments.Hierarchical generalized linear models with spatiotemporal clustering were used to identify significant ERPs associated with the behavioral outcome of DS-IAT (D scores) and group differences. <br><br>RESULTS: Behavioral results (D scores) showed that the adolescents with SIBS had stronger implicit associations between "death" and "self" than the healthy group (P=.02). Within adolescents with SIBS, participants with stronger implicit associations between "death" and "self" reported more difficulty in controllability of suicidal ideation in the past 2 weeks based on the Columbia-Suicide Severity Rating Scale (P=.03). For the ERP data, the D scores and N100 component over the left parieto-occipital cortex had significant correlations. Significant group differences without behavioral correlation were observed for a second N100 cluster (P=.01), P200 (P=.02), and late positive potential (5 clusters, all P≤.02). Exploratory predictive models combining both neurophysiological and clinical measures distinguished adolescents with SIBS from healthy adolescents. <br><br>CONCLUSIONS: Our results suggest that N100 may be a marker of attentional resources involved in the distinction of stimuli that are congruent or incongruent to associations between death and self. Combined clinical and event-related potential measures may have utility in future refinements of assessment and treatment approaches for adolescents with suicidality.<p />  <p>Language: en</p>
LA  - en
SN  - 1461-1457
UR  - http://dx.doi.org/10.1093/ijnp/pyad039
ID  - ref1
ER  -