TY  - JOUR
PY  - 2023//
TI  - Association between overt aggression and anhedonia in patients with major depressive disorder during the acute phase
JO  - Journal of psychiatric research
A1  - Xu, Chuchen
A1  - Wang, Fan
A1  - Huang, Qinte
A1  - Lyu, Dongbin
A1  - Wu, Chenglin
A1  - Cao, Tongdan
A1  - Zhao, Jie
A1  - Wang, Meiti
A1  - Zhou, Ni
A1  - Yang, Weichieh
A1  - Chen, Yiming
A1  - Wei, Zheyi
A1  - Xie, Bin
A1  - Hong, Wu
SP  - 41
EP  - 47
VL  - 165
IS  - 
N2  - OBJECTIVE: To explore the factors influencing anhedonia at baseline and use them as confounding factors. To further investigate the correlation between overt aggression and anhedonia during the acute phase of major depressive disorder. <br><br>METHODS: In this eight-week prospective study, 384 major depressive disorder patients were recruited from the outpatient section of Shanghai Mental Health Center from May 1, 2017, to October 30, 2018. Standard treatments were performed with escitalopram or venlafaxine for participants. Depressive symptoms, overt aggression, and anhedonia were assessed using the 17-item Hamilton Rating Scale for Depression, Modified Overt Aggression Scale, and Snaith-Hamilton Pleasure Scale at baseline, and in the 4th and 8th weeks. <br><br>RESULTS: Obsessive-compulsive symptoms and the duration of untreated psychosis were positively associated with aggression (P < 0.05). Patients with aggressive behaviour had worse cognitive impairment and severe anhedonia of pleasurable sensory experiences (P < 0.05). For anhedonia, being female (tau_b = -0.23, P = 0.012) was a protective factor, while number of recurrent, melancholic features, current obsessions, previous combination drug therapies, depressive symptoms, and aggressive behaviour were risk factors (P < 0.05). Social anhedonia related to interests/pastimes, and pleasurable sensory experiences were more severe in major depressive disorder patients with aggressive behaviour in the acute phase (P < 0.05). <br><br>CONCLUSIONS: Anhedonia persisted in major depressive disorder patients with aggressive behaviour after standardized treatment during the acute phase. Being female protected the pleasures from social interaction and sensory experience. However, the number of depressive episodes, melancholic features, current obsessive symptoms, previous combination drug therapies, depressive symptoms, and aggressive behaviour was positively associated with anhedonia.<p />  <p>Language: en</p>
LA  - en
SN  - 0022-3956
UR  - http://dx.doi.org/10.1016/j.jpsychires.2023.07.013
ID  - ref1
ER  -