TY  - JOUR
PY  - 2023//
TI  - Epigenomic and transcriptomic alterations in deep-layer pyramidal neurons of individuals who died by suicide with histories of early-life adversity
JO  - Biological psychiatry
A1  - Almeida, Daniel
A1  - Suderman, Matthew
A1  - Nagy, Corina
A1  - Mechaward, Naguib
A1  - Turecki, Gustavo
SP  - S38
EP  - S39
VL  - 93
IS  - 9
N2  - Early-life adversity (ELA) is a major public health concern that significantly increases the lifetime risk for suicide. Deep-layer pyramidal neurons (DLPNs) are important players in the microcircuitry of the PFC, which have been associated with ELA. In the present study we aimed to characterize long-term alterations to the epigenome and transcriptome of DLPNs associated with ELA.<p />  <p>Language: en</p>
LA  - en
SN  - 0006-3223
UR  - http://dx.doi.org/10.1016/j.biopsych.2023.02.112
ID  - ref1
ER  -