TY  - JOUR
PY  - 2023//
TI  - Prevalence and impact of recreational drug use in patients with acute cardiovascular events
JO  - Heart
A1  - Pezel, Théo
A1  - Dillinger, Jean-Guillaume
A1  - Trimaille, Antonin
A1  - Delmas, Clément
A1  - Piliero, Nicolas
A1  - Bouleti, Claire
A1  - Pommier, Thibaut
A1  - El Ouahidi, Amine
A1  - Andrieu, Stéphane
A1  - Lattuca, Benoit
A1  - Rossanaly Vasram, Reza
A1  - Fard, Damien
A1  - Noirclerc, Nathalie
A1  - Bonnet, Guillaume
A1  - Goralski, Marc
A1  - Elbaz, Meyer
A1  - Deney, Antoine
A1  - Schurtz, Guillaume
A1  - Docq, Clemence
A1  - Roubille, Francois
A1  - Fauvel, Charles
A1  - Bochaton, Thomas
A1  - Aboyans, Victor
A1  - Boccara, Franck
A1  - Puymirat, Etienne
A1  - Batisse, Anne
A1  - Steg, Gabriel
A1  - Vicaut, Eric
A1  - Henry, Patrick
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: While recreational drug use is a risk factor for cardiovascular events, its exact prevalence and prognostic impact in patients admitted for these events are not established. We aimed to assess the prevalence of recreational drug use and its association with in-hospital major adverse events (MAEs) in patients admitted to intensive cardiac care units (ICCU). <br><br>METHODS: In the Addiction in Intensive Cardiac Care Units (ADDICT-ICCU) study, systematic screening for recreational drugs was performed by prospective urinary testing all patients admitted to ICCU in 39 French centres from 7 to 22 April 2021. The primary outcome was prevalence of recreational drug detection. In-hospital MAEs were defined by death, resuscitated cardiac arrest, or haemodynamic shock. <br><br>RESULTS: Of 1499 consecutive patients (63±15 years, 70% male), 161 (11%) had a positive test for recreational drugs (cannabis 9.1%, opioids 2.1%, cocaine 1.7%, amphetamines 0.7%, 3,4-methylenedioxymethamphetamine (MDMA) 0.6%). Only 57% of these patients declared recreational drug use. Patients who used recreational drugs exhibited a higher MAE rate than others (13% vs 3%, respectively, p<0.001). Recreational drugs were associated with a higher rate of in-hospital MAEs after adjustment for comorbidities (OR 8.84, 95% CI 4.68 to 16.7, p<0.001). After adjustment, cannabis, cocaine, and MDMA, assessed separately, were independently associated with in-hospital MAEs. Multiple drug detection was frequent (28% of positive patients) and associated with an even higher incidence of MAEs (OR 12.7, 95% CI 4.80 to 35.6, p<0.001). <br><br>CONCLUSION: The prevalence of recreational drug use in patients hospitalised in ICCU was 11%. Recreational drug detection was independently associated with worse in-hospital outcomes. CLINICAL TRIAL REGISTRATION: NCT05063097.<p />  <p>Language: en</p>
LA  - en
SN  - 1355-6037
UR  - http://dx.doi.org/10.1136/heartjnl-2023-322520
ID  - ref1
ER  -