TY  - JOUR
PY  - 2023//
TI  - Effect modification of cortisol on the associations between obsessive-compulsive symptoms on suicidality in patients with acute coronary syndrome
JO  - Psychiatry investigation
A1  - Park, Jin-Young
A1  - Kim, Ju-Wan
A1  - Kang, Hee-Ju
A1  - Choi, Wonsuk
A1  - Lee, Ju-Yeon
A1  - Kim, Sung-Wan
A1  - Shin, Il-Seon
A1  - Ahn, Youngkeun
A1  - Jeong, Myung Ho
A1  - Kim, Jae-Min
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE  Obsessive-compulsive symptoms (OCS) and suicidal ideation (SI) are common in patients with acute coronary syndrome (ACS). This study investigated the associations of OCS and serum cortisol levels with SI, and further evaluated the possible modifying effects of cortisol on the associations between OCS and SI in acute and chronic phases of ACS.   Methods  In total, 969 ACS patients were recruited from a tertiary university hospital in Korea within 2 weeks of disease onset and evaluated in terms of OCS (using the OCS dimension of the Symptom Checklist-90-Revised), serum cortisol levels, and SI (using the "suicidal thoughts" item of the Montgomery-Åsberg Depression Rating Scale). Covariates included sociodemographics, depression, vascular risk factors, and disease severity. After 1 year, 711 patients were re-evaluated in terms of SI. Logistic regression analysis was performed with adjustment for covariates.   Results  Higher OCS was significantly associated with SI both at baseline and follow-up. Serum cortisol showed no such association, but modified the association between OCS and SI. That was the associations were significant only in the higher but not in the lower serum cortisol levels, with significant interaction terms after adjusted for relevant covariates.   Conclusion  Evaluating OCS and serum cortisol levels at the acute phase could improve the accuracy of clinical predictions of SI both in the acute and chronic phases of ACS.<p />  <p>Language: en</p>
LA  - en
SN  - 1738-3684
UR  - http://dx.doi.org/10.30773/pi.2023.0085
ID  - ref1
ER  -