TY - JOUR PY - 2023// TI - A review of psilocybin: chemistry, clinical uses and future research directions JO - Australian journal of chemistry A1 - Milliken, Eliza A1 - Galettis, Peter A1 - Martin, Jenny A1 - Milliken, Eliza A1 - Galettis, Peter A1 - Martin, Jenny SP - 258 EP - 263 VL - 76 IS - 5 N2 - Classic psychedelics such as psilocybin, ketamine and lysergic acid diethylamide (LSD) are 5HT2A serotonin receptor agonists that produce individualised subjective affects. Today, public interest in psychedelic medicine has reached a fervour but the evidence for clinical benefit still lags. Psilocybin and psilocin are tryptophan based alkaloids found worldwide in mushrooms of the genera Psilocybe, Panaeolus, Conocybe, Gymnopilus, Stropharia, Pluteus and Panaeolina. This review addresses the current evidence base for psilocybin as a clinical medicine, the general chemistry and proposed mechanism of its therapeutic effect and future research directions for psilocybin based therapies.
Language: en
LA - en SN - 0004-9425 UR - http://dx.doi.org/10.1071/CH23010 ID - ref1 ER -