TY  - JOUR
PY  - 2023//
TI  - Endocannabinoid system and aggression across animal species
JO  - Neuroscience and biobehavioral reviews
A1  - Migliaro, Martin
A1  - Ruiz-Contreras, Alejandra E.
A1  - Herrera-Solís, Andrea
A1  - Méndez-Díaz, Mónica
A1  - Prospéro-García, Oscar E.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - This narrative review article summarizes the current state of knowledge regarding the relationship between the endocannabinoid system (ECS) and aggression across multiple vertebrate species. Experimental evidence indicates that acute administration of phytocannabinoids, synthetic cannabinoids, and the pharmacological enhancement of endocannabinoid signaling decreases aggressive behavior in several animal models. However, research on the chronic effects of cannabinoids on animal aggression has yielded inconsistent findings, indicating a need for further investigation. Cannabinoid receptors, particularly cannabinoid receptor type 1, appear to be an important part of the endogenous mechanism involved in the dampening of aggressive behavior. Overall, this review underscores the importance of the ECS in regulating aggressive behavior and provides a foundation for future research in this area.<p />  <p>Language: en</p>
LA  - en
SN  - 0149-7634
UR  - http://dx.doi.org/10.1016/j.neubiorev.2023.105375
ID  - ref1
ER  -