TY  - JOUR
PY  - 2023//
TI  - Case report: Reversible splenial lesion syndrome caused by diquat poisoning
JO  - Frontiers in neurology
A1  - Dai, Ping
A1  - Sun, Jin
A1  - Yu, Zhongkai
A1  - Zhang, Tongyue
A1  - Wen, Zixin
A1  - Jian, Tianzi
A1  - Guo, Lanlan
A1  - Genjiafu, Aerbusili
A1  - Kan, Baotian
A1  - Zhang, Binbin
A1  - Jian, Xiangdong
SP  - e1178272
EP  - e1178272
VL  - 14
IS  - 
N2  - Diquat (DQ), chemically known as 1,1 '-ethylene-2,2' -bipyridine, is a non-selective herbicide for leaf removal and drying. It has toxic effects on central nervous system cells, and toxic neurological lesions include axonal degeneration and pontine myelolysis. At the same time, DQ can also affect the activity of dopaminergic nerve cells through oxidative stress, causing degeneration and reducing dopamine uptake. With the increasing application of DQ in agricultural production, the clinical reports of neurotoxicity caused by acute DQ poisoning are also increasing. At present, DQ rapid-phase-related toxic encephalopathy mainly involves the pons, midbrain, basal ganglia, thalamus and other brain regions. However, this case is unusual in that the lesion mainly involved the splenium of the corpus callosum. It is also the first time to be reported.<p />  <p>Language: en</p>
LA  - en
SN  - 1664-2295
UR  - http://dx.doi.org/10.3389/fneur.2023.1178272
ID  - ref1
ER  -