TY  - JOUR
PY  - 2023//
TI  - Microstructural organization of distributed white matter associated with fine motor control in US service members with mild traumatic brain injury
JO  - Journal of neurotrauma
A1  - Wade, Benjamin
A1  - Tate, David F.
A1  - Kennedy, Eamonn
A1  - Bigler, Erin D. PhD
A1  - York, Gerald
A1  - Taylor, Brian
A1  - Troyanskaya, Maya
A1  - Hovenden, Elizabeth
A1  - Goodrich-Hunsaker, Naomi J.
A1  - Newsome, Mary
A1  - Dennis, Emily L.
A1  - Abildskov, Tracy J.
A1  - Pugh, Mary Jo
A1  - Walker, William C.
A1  - Kenney, Kimbra
A1  - Betts, Aaron M.
A1  - Shih, Robert
A1  - Welsh, Robert
A1  - Wilde, Elisabeth A.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - Mild traumatic brain injury (mTBI) is the most common form of brain injury. While most individuals recover from mTBI, roughly 20% experience persistent symptoms, potentially including reduced fine motor control. We investigate relationships between regional white matter organization and subcortical volumes associated with performance on the Grooved Pegboard (GPB) test in a large cohort of military Service Members and Veterans (SM&Vs) with and without a history of mTBI(s). Participants were enrolled in the Long-term Impact of Military-relevant Brain Injury Consortium- Chronic Effects of Neurotrauma Consortium. SM&Vs with a history of mTBI(s) (n=847) and without mTBI (n=190) underwent MRI and the GPB test. We first examined between-group differences in GPB completion time. We then investigated associations between GPB performance and regional structural imaging measures (tractwise diffusivity, subcortical volumes, and cortical thickness) in SM&Vs with a history of mTBI(s). Lastly, we explored whether mTBI history moderated associations between imaging measures and GPB performance. SM&Vs with mTBI(s) performed worse than those without mTBI(s) on the non-dominant hand GPB test at a trend level (p<0.1). Higher FA of tracts including the posterior corona radiata, superior longitudinal fasciculus, and uncinate fasciculus were associated with better GPB performance in the dominant hand in SM&Vs with mTBI(s). These findings support that the organization of several white matter bundles are associated with fine motor performance in SM&Vs. We did not observe that mTBI history moderated associations between regional FA and GPB test completion time, suggesting that chronic mTBI may not significantly influence fine motor control.<p />  <p>Language: en</p>
LA  - en
SN  - 0897-7151
UR  - http://dx.doi.org/10.1089/neu.2022.0094
ID  - ref1
ER  -