TY  - JOUR
PY  - 2023//
TI  - Intimate partner violence is associated with cytomegalovirus among young women in rural South Africa: an HPTN 068 analysis
JO  - Global public health
A1  - Kelly, Nicole K.
A1  - Gómez-Olivé, F. Xavier
A1  - Wagner, L. Danielle
A1  - Aiello, Allison E.
A1  - Kahn, Kathleen
A1  - Pettifor, Audrey
A1  - Stoner, Marie C. D.
SP  - e2258962
EP  - e2258962
VL  - 18
IS  - 1
N2  - ABSTRACTStressful life circumstances (e.g. violence and poverty) have been associated with elevated biomarkers, including C-reactive protein (CRP), cytomegalovirus (CMV), and herpes simplex virus type-1 (HSV-1), among older adults in high-income settings. Yet, it remains unknown whether these relationships exist among younger populations in resource-limited settings. We therefore utilised a cohort of 1,279 adolescent girls and young women (AGYW) from the HIV Prevention Trials Network 068 study in rural South Africa to examine the associations between 6 hypothesized stressors (intimate partner violence (IPV), food insecurity, depression, socioeconomic status (SES), HIV, childhood violence) and 3 biomarkers that were measured using dried blood spots (CRP, CMV, and HSV-1). Ordinal logistic regression estimated the lagged and cross-sectional associations between each stressor and each biomarker. IPV was cross-sectionally associated with elevated CMV (OR = 2.45, 95% CI = 1.05,5.72), while low SES was cross-sectionally associated with reduced CMV (OR = 0.73, 95% CI = 0.58,0.93). AGYW with HIV had elevated biomarkers cross-sectionally (CRP: OR = 1.51, 95% CI = 1.08,2.09; CMV: OR = 1.86, 95% CI = 1.31,2.63; HSV-1: OR = 1.68, 95% CI = 1.17,2.41) and in a lagged analysis. The association between violence and CMV could help explain how violence results in stress and subsequently worse health among AGYW; however, additional research is needed to disentangle the longitudinal nature of IPV and stress.<p />  <p>Language: en</p>
LA  - en
SN  - 1744-1692
UR  - http://dx.doi.org/10.1080/17441692.2023.2258962
ID  - ref1
ER  -