TY  - JOUR
PY  - 2023//
TI  - Hippocampal volume loss in individuals with a history of non-fatal opioid overdose
JO  - Addiction biology
A1  - Todaro, Dustin R.
A1  - Li, Xinyi
A1  - Pereira-Rufino, Laís S.
A1  - Manza, Peter
A1  - Nasrallah, Ilya M.
A1  - Das, Sandhitsu
A1  - Childress, Anna Rose
A1  - Kranzler, Henry R.
A1  - Volkow, Nora D.
A1  - Langleben, Daniel D.
A1  - Shi, Zhenhao
A1  - Wiers, Corinde E.
SP  - e13336
EP  - e13336
VL  - 28
IS  - 10
N2  - Incidence of opioid-related overdoses in the United States has increased dramatically over the past two decades. Despite public emphasis on overdose fatalities, most overdose cases are not fatal. Although there are case reports of amnestic syndromes and acute injury to the hippocampus following non-fatal opioid overdose, the effects of such overdoses on brain structure are poorly understood. Here, we investigated the neuroanatomical correlates of non-fatal opioid overdoses by comparing hippocampal volume in opioid use disorder (OUD) patients who had experienced an opioid overdose (OD; N = 17) with those who had not (NOD; N = 32). Voxel-based morphometry showed lower hippocampal volume in the OD group than in the NOD group, which on post hoc analysis was evident in the left but not the right hippocampus. These findings strengthen the evidence that hippocampal injury is associated with non-fatal opioid overdose, which is hypothesized to underlie overdose-related amnestic syndrome.<p />  <p>Language: en</p>
LA  - en
SN  - 1355-6215
UR  - http://dx.doi.org/10.1111/adb.13336
ID  - ref1
ER  -