TY  - JOUR
PY  - 2023//
TI  - Association between adverse childhood experiences and suicidal behavior in schizophrenia spectrum disorders: a systematic review and meta-analysis
JO  - Psychiatry research
A1  - Baldini, Valentina
A1  - Stefano, Ramona Di
A1  - Rindi, Lorenzo Vittorio
A1  - Ahmed, Anthony O.
A1  - Koola, Maju Mathew
A1  - Solmi, Marco
A1  - Papola, Davide
A1  - De Ronchi, Diana
A1  - Barbui, Corrado
A1  - Ostuzzi, Giovanni
SP  - e115488
EP  - e115488
VL  - 329
IS  - 
N2  - Assessing and managing suicide behaviors is highly relevant to individuals with schizophrenia spectrum disorders. Our study aims to assess the association between adverse childhood experiences and suicidal behaviors in individuals with schizophrenia spectrum disorders. We included observational studies comparing the probability of suicide behaviors in adults with schizophrenia spectrum disorders exposed and unexposed to adverse childhood experiences. Odds ratio estimates were obtained by pooling data using a random-effects pairwise meta-analysis. Standardized criteria were used to assess the strength of the association of the pooled estimate. We found 21 eligible studies reporting outcomes for 6257 individuals from 11 countries. The primary outcome revealed an association between any suicidal behavior and adverse childhood experiences, which resulted "highly suggestive" according to validated Umbrella Criteria. Similarly, a positive association was confirmed for suicidal ideation and suicide attempt and for any subtype of adverse childhood experience. This meta-analysis showed that exposure to adverse childhood experiences strongly increases the probability of suicide behaviors in people with schizophrenia spectrum disorders.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2023.115488
ID  - ref1
ER  -