TY  - JOUR
PY  - 2023//
TI  - Response to letter to the editors regarding 'a meta-regression of trial features predicting the effects of alcohol use disorder pharmacotherapies on drinking outcomes in randomized clinical trials: a secondary data analysis'
JO  - Alcohol and alcoholism
A1  - Grodin, Erica N.
A1  - Donato, Suzanna
A1  - Du, Han
A1  - Green, ReJoyce
A1  - Bujarski, Spencer
A1  - Ray, Lara A.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - We received and read the letter to the Editors from Drs Guiraud and van den Brink regarding our article entitled 'A Meta-Regression of Trial Features Predicting the Effects of Alcohol Use Disorder Pharmacotherapies on Drinking Outcomes in Randomized Clinical Trials: A Secondary Data Analysis'.     We believe that the comments provided by the authors are derived from differing findings in their recently published paper 'Sodium Oxybate for Alcohol Dependence: A Network Meta-Regression Analysis Considering Population Severity at Baseline and Treatment Duration'. We would like to highlight that the two manuscripts took different approaches to answer different questions. Our manuscript used a meta-regression approach with two arms (pharmacotherapy treatment vs. control) to answer the question of what trial features predict the efficacy of pharmacotherapies on drinking outcomes across a range of 19 pharmacotherapies. Guiraud et al. used a network meta-regression approach focused solely on one pharmacotherapy, sodium oxybate, as a treatment for alcohol use disorder. It is therefore unsurprising that different methodological approaches to solve different questions resulted in different answers...<p />  <p>Language: en</p>
LA  - en
SN  - 0735-0414
UR  - http://dx.doi.org/10.1093/alcalc/agad066
ID  - ref1
ER  -