TY  - JOUR
PY  - 2023//
TI  - Molecularly imprinted polymers (MIP) combined with Raman spectroscopy for selective detection of Δ⁹-tetrahydrocannabinol (THC)
JO  - Talanta
A1  - Yeganegi, Arian
A1  - Fardindoost, Somayeh
A1  - Tasnim, Nishat
A1  - Hoorfar, Mina
SP  - e125271
EP  - e125271
VL  - 267
IS  - 
N2  - A proof-of-concept sensor is developed for the sensitive and selective detection of Trans-Δ⁹-tetrahydrocannabinol (THC) based on a molecularly imprinted polymer (MIP) synthesized with a THC template which was analyzed using Raman spectroscopy to perform label-free monitoring of THC based on a single identifying Raman peak. The MIP sensor produced a peak at 1614 cm(-1) in the Raman spectrum originating from the THC target molecule, allowing for the selective quantification of bound THC with the lowest detection limit of 250 ppm. A higher sensitivity of the MIP to the THC target molecule was observed compared to the non-imprinted polymer (NIP) control which confirmed the presence of THC-specific recognition sites within the synthesized MIP sensing material. The selectivity of this MIP-based sensor was determined by measuring the Raman spectrum of MIP exposed to Cannabidiol (CBD), ethanol, and acetone.    Keywords: Cannabis impaired driving; Ethanol impaired driving; <p />  <p>Language: en</p>
LA  - en
SN  - 0039-9140
UR  - http://dx.doi.org/10.1016/j.talanta.2023.125271
ID  - ref1
ER  -