TY  - JOUR
PY  - 2023//
TI  - The effects of migraine and traumatic brain injury on subjective cognitive functioning in veterans in the Million Veteran Program
JO  - Archives of clinical neuropsychology
A1  - Ozturk, Erin
A1  - Merritt, Victoria
A1  - Afari, Niloofar
A1  - Gasperi, Marianna
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - OBJECTIVE: The relationship between migraine and cognitive symptoms in Veterans is a complex issue, made more challenging by the high prevalence of traumatic brain injury (TBI) in this population. This study examined the relationship between migraine, TBI, and subjective cognitive function. <br><br>METHOD: Participants included 338,217 Veterans enrolled in the Million Veteran Program who completed the Medical Outcomes Study Cognitive Functioning Scale Revised (MOS-Cog-R), a self-report measure of cognitive functioning. Veterans were categorized into the following groups: (1) both migraine and TBI history (n = 7828), (2) migraine-only (n = 22,252), (3) TBI-only (n = 24,078), and (4) no history of migraine or TBI (n = 284,059). MOS-Cog-R scales were compared across groups using the Kruskal-Wallis Test for omnibus differences and Dunn's test and Cliff's Delta for effect size calculations of differences between groups. <br><br>RESULTS: The migraine/TBI group reported the highest prevalence of cognitive symptoms across all domains (range: 76.1% for confusion to 90.5% for forgetfulness). In contrast, the no migraine/TBI group had the lowest prevalence of cognitive problems (range: 32.0% for confusion to 63.7% for forgetfulness). All omnibus group differences were statistically significant (p < 0.001), and nearly all pairwise comparisons were significant, except for some of the migraine-only vs. TBI-only group comparisons. <br><br>CONCLUSION: Results showed a "dose-response" relationship between diagnostic group and subjective cognitive symptoms, such that the migraine/TBI group fared the worst, followed by the TBI-only and migraine-only groups, and finally the no migraine/TBI group. <br><br>FINDINGS set the stage for follow-up work to be conducted within MVP that will address the neurobiological underpinnings of cognitive distress in this population.<p />  <p>Language: en</p>
LA  - en
SN  - 0887-6177
UR  - http://dx.doi.org/10.1093/arclin/acad067.175
ID  - ref1
ER  -