TY  - JOUR
PY  - 2023//
TI  - Biokinetic model analysis with DTPA administration for a case of accidental inhalation of actinides in Japan
JO  - Radiation protection dosimetry
A1  - Tani, Kotaro
A1  - Ishigure, Nobuhito
A1  - Kim, Eunjoo
A1  - Tominaga, Takako
A1  - Tatsuzaki, Hideo
A1  - Akashi, Makoto
A1  - Kurihara, Osamu
SP  - 2025
EP  - 2029
VL  - 199
IS  - 15-16
N2  - Accidental inhalation intake of plutonium isotopes and 241Am occurred at a Pu research facility in Japan in 2017, and the five workers involved in this accident were treated by the administration of Ca/Zn-diethylenetriaminepentaacetic acid (DTPA). For the worker who was most internally exposed, the therapy was continued over 1 y after the accident. Urinary samples collected before and after each administration were subject to bioassay to evaluate the efficacy of the dose reduction. This study performed numerical analyses using a biokinetic model dealing with 241Am-DTPA with reference to the European Coordinated Network on Radiation Dosimetry approach, which assumes that the complex of actinides and Ca/Zn-DTPA is generated in the designated compartments in the biokinetic model. The results of the model prediction well captured the trend of the observed urinary excretion in the long-term bioassay and would be useful to evaluate the efficacy of the Ca/Zn-DTPA administration for the worker involved in the accident.<p />  <p>Language: en</p>
LA  - en
SN  - 0144-8420
UR  - http://dx.doi.org/10.1093/rpd/ncac224
ID  - ref1
ER  -