TY  - JOUR
PY  - 2023//
TI  - Plasma neurofilament light chain in association to late-life depression in the general population
JO  - Psychiatry and the Clinical Neurosciences
A1  - Schuurmans, Isabel K.
A1  - Ghanbari, Mohsen
A1  - Cecil, Charlotte A. M.
A1  - Ikram, M. Arfan
A1  - Luik, Annemarie I.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - AIM: Investigating what is underlying late-life depression is becoming increasingly important with the rapidly growing elderly population. Yet, the associations between plasma biomarkers of neuroaxonal damage and late-life depression remain largely unclear. Therefore, we determined cross-sectional and longitudinal associations of neurofilament light chain (NfL) with depression in middle-aged and elderly individuals, and total tau, β-amyloid 40 and 42 for comparison. <br><br>METHODS: We included 3,895 participants (71.78 years (SD=7.37), 53.4% women) from the population-based Rotterdam Study. Between 2002 and 2005, NfL, total tau, β-amyloid 40 and β-amyloid 42 were determined in blood and depressive symptoms were measured with the Center for Epidemiologic Studies Depression scale (CES-D). Incident depressive events (clinically relevant depressive symptoms, depressive syndromes, major depressive disorders) were measured prospectively with the CES-D, a clinical interview and follow-up of medical records over a median follow-up of 7.0 years (interquartile range 1.80). We used linear and Cox proportional hazard regression models. <br><br>RESULTS: Each log(2) pg/mL increase in NfL was cross-sectionally associated with more depressive symptoms (adjusted mean difference: 0.32, 95%CI 0.05-0.58), as well as with an increased risk of any incident depressive event over time (hazard ratio: 1.22, 95%CI 1.01-1.47). Further, more amyloid-β 40 was cross-sectionally associated with more depressive symptoms (adjusted mean difference: 0.70, 95%CI 0.15-1.25). <br><br>CONCLUSION: Higher levels of NfL are cross-sectionally associated with more depressive symptoms and a higher risk of incident depressive events longitudinally. The association was stronger for NfL compared to other plasma biomarkers, suggesting a potential role of neuroaxonal damage in developing late-life depression. This article is protected by copyright. All rights reserved.<p />  <p>Language: en</p>
LA  - en
SN  - 1323-1316
UR  - http://dx.doi.org/10.1111/pcn.13608
ID  - ref1
ER  -