TY  - JOUR
PY  - 2023//
TI  - Childhood trauma moderates schizotypy-related brain morphology: analyses of 1182 healthy individuals from the ENIGMA schizotypy working group
JO  - Psychological medicine
A1  - Quidé, Yann
A1  - Watkeys, Oliver J.
A1  - Tonini, Emiliana
A1  - Grotegerd, Dominik
A1  - Dannlowski, Udo
A1  - Nenadic, Igor
A1  - Kircher, Tilo
A1  - Krug, Axel
A1  - Hahn, Tim
A1  - Meinert, Susanne
A1  - Goltermann, Janik
A1  - Gruber, Marius
A1  - Stein, Frederike
A1  - Brosch, Katharina
A1  - Wroblewski, Adrian
A1  - Thomas-Odenthal, Florian
A1  - Usemann, Paula
A1  - Straube, Benjamin
A1  - Alexander, Nina
A1  - Leehr, Elisabeth J.
A1  - Bauer, Jochen
A1  - Winter, Nils R.
A1  - Fisch, Lukas
A1  - Dohm, Katharina
A1  - Rossler, Wulf
A1  - Smigielski, Lukasz
A1  - Derosse, Pamela
A1  - Moyett, Ashley
A1  - Houenou, Josselin
A1  - Leboyer, Marion
A1  - Gilleen, James
A1  - Thomopoulos, Sophia I.
A1  - Thompson, Paul M.
A1  - Aleman, Andre
A1  - Modinos, Gemma
A1  - Green, Melissa J.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND: Schizotypy represents an index of psychosis-proneness in the general population, often associated with childhood trauma exposure. Both schizotypy and childhood trauma are linked to structural brain alterations, and it is possible that trauma exposure moderates the extent of brain morphological differences associated with schizotypy. <br><br>METHODS: We addressed this question using data from a total of 1182 healthy adults (age range: 18-65 years old, 647 females/535 males), pooled from nine sites worldwide, contributing to the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Schizotypy working group. All participants completed both the Schizotypal Personality Questionnaire Brief version (SPQ-B), and the Childhood Trauma Questionnaire (CTQ), and underwent a 3D T1-weighted brain MRI scan from which regional indices of subcortical gray matter volume and cortical thickness were determined. <br><br>RESULTS: A series of multiple linear regressions revealed that differences in cortical thickness in four regions-of-interest were significantly associated with interactions between schizotypy and trauma; subsequent moderation analyses indicated that increasing levels of schizotypy were associated with thicker left caudal anterior cingulate gyrus, right middle temporal gyrus and insula, and thinner left caudal middle frontal gyrus, in people exposed to higher (but not low or average) levels of childhood trauma. This was found in the context of morphological changes directly associated with increasing levels of schizotypy or increasing levels of childhood trauma exposure. <br><br>CONCLUSIONS: These results suggest that alterations in brain regions critical for higher cognitive and integrative processes that are associated with schizotypy may be enhanced in individuals exposed to high levels of trauma.<p />  <p>Language: en</p>
LA  - en
SN  - 0033-2917
UR  - http://dx.doi.org/10.1017/S0033291723003045
ID  - ref1
ER  -