TY  - JOUR
PY  - 2023//
TI  - Relationship between evacuation after the Great East Japan Earthquake and new-onset hyperuricemia: a 7-year prospective longitudinal study of the Fukushima Health Management Survey
JO  - PLoS one
A1  - Honda, Kazuya
A1  - Okazaki, Kanako
A1  - Tanaka, Kenichi
A1  - Kobari, Eri
A1  - Kazama, Sakumi
A1  - Hashimoto, Shigeatsu
A1  - Ohira, Tetsuya
A1  - Sakai, Akira
A1  - Yasumura, Seiji
A1  - Maeda, Masaharu
A1  - Yabe, Hirooki
A1  - Hosoya, Mitsuaki
A1  - Takahashi, Atsushi
A1  - Harigane, Mayumi
A1  - Nakano, Hironori
A1  - Hayashi, Fumikazu
A1  - Nagao, Masanori
A1  - Shimabukuro, Michio
A1  - Ohto, Hitoshi
A1  - Kamiya, Kenji
A1  - Kazama, Junichiro J.
SP  - e0293459
EP  - e0293459
VL  - 18
IS  - 10
N2  - INTRODUCTION: On March 11, 2011, the Great East Japan Earthquake occurred in Japan, with a nuclear accident subsequently occurring at the Fukushima Daiichi Nuclear Power Plant. The disaster forced many evacuees to change particular aspects of their lifestyles. However, the effect of evacuation on the new-onset of hyperuricemia have not been sufficiently elucidated. This study assessed the association between evacuation and new-onset hyperuricemia after the earthquake based on the Fukushima Health Management Survey from a lifestyle and socio-psychological perspective. <br><br>MATERIALS AND METHODS: This is a 7-year prospective longitudinal study included 18,140 residents (6,961 men and 11,179 women) with non-hyperuricemia who underwent both the Comprehensive Health Check and the Mental Health and Lifestyle Survey in fiscal year 2011. Associations between new-onset hyperuricemia and lifestyle- and disaster-related factors, including evacuation, were estimated using a Cox proportional hazards regression model analysis. Hyperuricemia was defined as uric acid levels > 7.0 mg/dL for men and > 6.0 mg/dL for women. <br><br>RESULTS: During a median follow-up of 4.3 years, 2,996 participants (1,608 men, 23.1%, 1,388 women, 12.4%) newly developed hyperuricemia. Significant associations were observed between evacuation and onset of hyperuricemia in women (adjusted hazard ratio 1.18, 95% confidence interval, 1.05-1.32, p = 0.007), but not in men (adjusted hazard ratio 1.11, 95% confidence interval, 0.99-1.24, p = 0.067). <br><br>DISCUSSION: Evacuation after a natural disaster is an independent risk factor for the new-onset of hyperuricemia in women. The possibility of hyperuricemia developing in response to natural disasters should be considered.<p />  <p>Language: en</p>
LA  - en
SN  - 1932-6203
UR  - http://dx.doi.org/10.1371/journal.pone.0293459
ID  - ref1
ER  -