TY  - JOUR
PY  - 2023//
TI  - Comparative mortality risks in two independent bipolar cohorts
JO  - Psychiatry research
A1  - Yocum, Anastasia K.
A1  - Friedman, Emily
A1  - Bertram, Holli S.
A1  - Han, Peisong
A1  - McInnis, Melvin G.
SP  - e115601
EP  - e115601
VL  - 330
IS  - 
N2  - OBJECTIVES: To compare mortality rates in bipolar disorder with common causes of mortality. <br><br>METHODS: Observational data from the Prechter Longitudinal Study of Bipolar Disorder (PLS-BD) of 1128 participants including 281 controls was analyzed using logistical regression to quantify mortality rates in comparison with common comorbidities and causes of death. Outcome and treatment measures, including ASRM, GAD-7, PHQ-9 and medication use were used to stratify those with bipolar disorder (BD) that are alive or deceased. A larger cohort of 10,735 existing BD patients with 7,826 controls (no psychiatric diagnosis) from the University of Michigan Health (U-M Health) clinics was used as replication, observational secondary data analysis. <br><br>RESULTS: The mortality rates are significantly different between those with BD and controls in both PLS-BD and U-M Health. Those with BD and are deceased have a higher percentage of elevated depression measures but show no difference in mania or anxiety measures nor medication use patterns. In both cohorts, a diagnosis of BD increases the odds of mortality greater than history of smoking or being older than ≥ 60-years of age. <br><br>CONCLUSION: BD was found to increase odds of mortality significantly and beyond that of a history of smoking. This finding was replicated in an independent sample.<p />  <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/10.1016/j.psychres.2023.115601
ID  - ref1
ER  -