TY  - JOUR
PY  - 2023//
TI  - Brief report: The influence of childhood trauma on the effects of delta-9-tetrahydrocannabinol in persons with opioid use disorder
JO  - American journal on addictions
A1  - Rogan, Michael
A1  - Nunes, Julio C.
A1  - Xie, Catherine Z.
A1  - Sofuoglu, Mehmet
A1  - Pittman, Brian
A1  - De Aquino, Joao P.
SP  - ePub
EP  - ePub
VL  - ePub
IS  - ePub
N2  - BACKGROUND AND OBJECTIVES: Childhood trauma (CT) increases addiction vulnerability. We examined CT's impact on delta-9-tetrahydrocannabinol (THC) effects. <br><br>METHODS: This is a post-hoc analysis of a randomized, placebo-controlled, crossover trial investigating the effects of oral THC (10, 20 mg) among 25 persons receiving methadone for opioid use disorder (OUD). <br><br>RESULTS: Greater CT was associated with lower aversive effects from higher THC doses (20 mg) (p = .006). <br><br>DISCUSSION AND CONCLUSIONS: CT may reduce the subjective aversive effects of THC, potentially leading to greater cannabis use in individuals with OUD. SCIENTIFIC SIGNIFICANCE: These findings offer insights into THC's risks versus benefits in OUD subgroups and emphasize assessing CT in OUD treatment and research.<p />  <p>Language: en</p>
LA  - en
SN  - 1055-0496
UR  - http://dx.doi.org/10.1111/ajad.13504
ID  - ref1
ER  -